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Dual-wavelength Narrow Linewidth Fiber Coupled Laser System lasers combines two wavelengths into one box and outputs from one optical fiber. It has the features that the linewidth of each wavelength is less than 0.1nm, which is widely used in Raman spectroscopy, biomedicine and dual wavelength metrology. Specification

Single-longitudinal-mode Laser Single-frequency lasers, that is single-longitudinal-mode lasers. Its characteristic is that the output laser mode satisfies both single transverse mode and single longitudinal mode. There is only one single longitudinal mode in the resonator tooscillate, and the output light intensity presents a Gaussian distribution. CNI offers single longitudinal mode (SLM) lasers with ultra narrow spectral line width and long coherence length, the wavelength are from 360nm to 1550nm.

Fine laser marking Today, the first one we want to introduce you is our lasers for marking application. Laser marking is a permanent process that uses a beam of concentrated light to create a lasting mark on a surface. CNI offers Q-switched DPSS lasers and Mini laser marking machines, avilable with 355 nm, 532 nm and 1064 nm.

High Energy Laser CNI can provide lamp-pumped and diode-pumped lasers with high pulse energy. Available with 266 nm, 355 nm, 532 nm, 1064 nm, 1573 nm, etc.. The single pulsed energy of 532 nm green laser can be up to 450 mJ and the energy of 1064 nm infrared laser can be up to 10

Laser power meter is used to measure laser power and power stability. CNI designed several laser power measurement instruments with the features of accuracy testing, easy operation, etc., which could fully meet customer's practical needs of laser power and power stability measurement. They are widely used in the research, teaching, medical science, industry and other fields. The power can not go beyond the range of the power meter when using it. ■ Testing Instrument: Power Meter Product Picture Model Power range Main Features Thermopile Laser Power Meter TS series (wide range) TS2+TP100 2mW-2W 1.Wavelength range: 0.19 -20µm 2. Damage threshold: 15kW/cm2 3. Power measurement range:2mW-15W 4. Sensitivity diameter: 14mm 5. Minimum measuring precision:0.1mW 6. SMA905/ FC fiber switch connector (Optional) TS5+TP100 5mW-5W TS15+TP100 10mW-15W TS35+TP100 10mW-35W 1. Wavelength range: 0.19 -25µm 2. Damage threshold: 40kW/cm2 3. Power measurement range: 10mW-50W 4. Sensitivity diameter: 22mm 5. Minimum measuring precision: 0.001W 6. SMA905/ FC fiber switch connector (Optional) TS50+TP100 10mW-50W TS100+TP100 0.5W-100W . Wavelength range: 0.19 -20µm 2. Damage threshold: 45kW/cm2 3. Power measurement range: 0.5W-100W 4. Sensitivity diameter: 25mm 5. Minimum measuring precision: 0.001W HS series (High Precision) HS1+TP100 100µW-1W 1. Wavelength range: 0.19 -15µm 2. Damage threshold: 1.5kW/cm2 3. Power measurement range: 100µW-5W 4. Sensitivity diameter: 8.5mm 5. Minimum measuring precision: 0.01mW 6. SMA905/ FC fiber switch connector (Optional) HS5+TP100 500µW-5W USB series (Multi-channel) TS2/TS5/TS15-USB TS35/TS50-USB TS100-USB HS1/HS5-USB 100µW-100W 1. Wavelength range:0.19 -25µm 2.Power measurement range: 100µW-100W 3.Single channel/multiple channel power measurement 4.PC upper computer software display measurement Photoelectric Laser Power meter PS100 series (High precision) PS100 2nW-100mW 1. Wavelength range: 320-1100nm 2. High precision: ±2% 3. Resolution: 2nW 4. Minimum measuring precision: 0.001nW ■ Examples of Testing Results High precision photoelectric power meter testing result Termopile power meter testing result

Gene sequencing is a new gene detection technology, which simply means to display the sequence of base ATGC in DNA/RNA molecules.Gene sequencing technology can be used to analyze and determine the full sequence of genes from blood or saliva, so as to target individual genes for prevention and treatment in advance. In 1977, Walter Gilbert and Frederick Sanger established DNA sequencing technology and won the Nobel Prize in chemistry in 1980.From there, the technology that will dominate the future of the life sciences is widely used in research. Over the past 40 years or so, gene sequencing has undergone many technological The first generation of gene sequencing technology (Sanger sequencing) is based on the sequencing principle of Sanger dideoxy termination method, combined with fluorescence labeling and capillary array electrophoresis technology to realize the automation of sequencing. The basic method is chain termination or degradation method.The method was then converted to fluorescent nucleotide labeling, capillary electrophoresis differentiation and laser detection, thus realizing the first generation of automated sequencing method. The second-generation sequencing (NGS) achieves high-throughput sequencing at the expense of reading length, and the sequence of hundreds of thousands to millions of nucleic acid molecules can be obtained simultaneously in one operation. The first generation of sequencing is synthetic termination sequencing, while the second generation of sequencing is pioneering in the introduction of reversible termination terminals, so as to achieve simultaneous synthesis and sequencing.The DNA is sequenced by a laser that excites a fluorescent signal during DNA replication, scanning it for special markers (commonly known as fluorescent molecular markers) carried by newly added bases. The second generation sequencing with high flux, low cost, short time sequencing and other advantages, quickly occupied the dominant position in sequencing in the global market, its application areas including noninvasive prenatal testing (NIPT), pre-implantation genetic diagnosis (PGD/PGS)/screening, genetic disease diagnosis, tumor diagnosis and individualized treatment, gene detection, pathogenic microorganism, etc. The third generation of DNA sequencing technology mainly includes three kinds: Helico Bioscience Single molecule sequencing technology, Pacific Bioscience Single molecule Realtime (SMRT) sequencing technology and Oxford Nanopore Single molecule sequencing technology (real-time sequencing of "electrical signal" changes brought by Nanopore). Compared with the previous two generations of sequencing technology, its biggest feature is single molecule sequencing, which does not require PCR amplification and can theoretically determine the nucleic acid sequence of infinite length.Therefore, the third generation sequencing technology is also known as single molecule DNA sequencing, that is, the modern optical, polymer, nano technology and other means to distinguish the difference between the base signal principle, in order to achieve the purpose of direct reading sequence information.Without the use of biological or chemical reagents, costs can be further reduced. The biggest problem with third-generation sequencing is the high error rate (15-40%).However, errors are random and do not have the bias of sequencing errors like the second-generation sequencing technology. Therefore, multiple sequencing can be used to effectively correct errors. The ability to efficiently activate the fluorescence of the four chemical markers of DNA nucleotide (ACGT) by laser, and the ability to accurately distinguish the four fluorescent dyes, are crucial to gene sequencing.Therefore, the choice of laser will directly affect the accuracy and efficiency of sequencing. At present, common wavelengths in the gene sequencing market are: 488 nm blue laser, 514 nm green laser, 532 nm green laser, 577nm yellow laser, 639nm red laser, 660nm red laser, 690nm red laser... In the research and development and experiment of companies or universities, in addition to the requirements of optical parameters of lasers, more needs are "customized" solutions.Simple ones such as optical fiber transmission, spot shaping, more complex ones such as multi-wavelength synthesis, high consistency between multiple wavelengths and so on.

The Photonics West is one of the large international optoelectronics exhibitions in the United States, and was held as scheduled in 2020. Here you can get access to advanced technologies, including the fields of biomedical photonics, industrial laser light sources, optoelectronic materials and devices, MEMS and MOEMS photonics technology and nanotechnology. CNI exhibited hot products such as compact diode laser, ultraviolet laser, single-frequency solid-state laser, Multi-wavelength fiber coupled laser system, fiber laser, laser sources for LIBS and Lidar, structured laser, laser power meter and spectrometer, etc.

Nowadays, laser technology is practically ubiquitous, and lasers are used in developing all manner of brilliant innovations. Up to now, more than ten thousand of academic papers have been publised by using CNI lasers, and the optical beam can be found in various practial applications. To memorize this milestone, we listed some applications in respect to our customers. 01Confocal Light Field Microscopy The institute of Neuroscence, Chinese Academy of Sciences, presents a new imaging method, confocal light field microscopy, to enable fast volumetric imaging deep into brain. They demonstrated the power of this method by recording whole brain calcium transients in freely swimming larval zebrafish and observed behaviorally correlated activities on single neurons during its prey capture. Furthermore, they captured neural activities and circulating blood cells over a volume ⌀ 800 μm x 150 μm at 70 Hz and up to 600 μm deep in the mice brain. Paper title: Capturing volumetric dynamics at high speed in the brain by confocal light field microscopy Periodical: bioRxiv, doi:https://doi.org/ 10.1101/ 2020.01.04.890624, page 23 473nm 1.5W laser for CLFM 02Handheld Photoacoustic Imaging With the aim of clinical translation, a photoacoustic imaging platform with a portable system size, a miniaturized imaging probe, and convenient handheld capability is of demand. Nayang Technilogical University had on expriement by adopting an ultrathin central-holed matrix array and a compact coaxial photoacoustic design, a water-free handheld photoacoustic imager is developed(weight:44g).This experiement uses a 15mj fiber coupled laser that customized by CNI,and its paper is pulished in IEEE transactions on Biomedical Enginnering. Paper title:Development of a handheld volumetric photoacoustic imaging system with a central-holed 2D matrix aperture. Periodical: IEEE Transactions on Biomedical Engineering · January 2020 DOI: 10.1109/TBME.2019.2963464, page 3 03 Photodynamic Therapy Antimicrobial photodynamic therapy (aPDT) leads to the generation of reactive oxygen species (ROS) that destroys bacterial cells in presence of a photosensitizer, visible light, and oxygen. Aligarh Muslim University has taken Enterococcus faEcalis and Streptococcus mutans as monospecies culture and their dualspecies culture biofilm. Antibacterial effect was evaluated by colony forming unit while antibiofilm action by crystal violet and congored binding assays. Finally they found that reactive oxygen species and singlet oxygen yield was found to be light dose dependent and antimicrobial photodynamic efficiency is directly related to the ROS production. They use a 630nm CNI laser to complete the experiement and published their paper in Photodiagnosis and Photodynamic Therapy, 2019 - Elsevier. Paper title: Photodynamic efficacy of toluidine blue O against mono species and dual species bacterial biofilm. Periodical: Photodiagnosis and Photodynamic Therapy, 2019 - Elsevier 04 Nitrogen-vacancy Center Detection Electron spin resonance (ESR) spectroscopy has broad applications in physics, chemistry, and biology. However, the traditional zero-fifield ESR (ZF-ESR) method has been rarely used due to the low sensitivity and the requirement of much larger samples than conventional ESR. The University of Science and Technology of China presents a method for deploying ZF-ESR spectroscopy at the nanoscale by using a highly sensitive quantum sensor, the nitrogen vacancy center in diamond. This method opens the door to practical applications of ZF-ESR spectroscopy, such as investigation of the structure and polarity information in spin-modifified organic and biological systems. They use a CNI 532nm laser and their paper is published in Nature Communications. Paper title: Nanoscale zero-fifield electron spin resonance spectroscopy Periodical: Nature Communications (2018) 9:1563 | DOI:10.1038/s41467-018-03969-4, page 2 05 Synthetic Biology Droplet microfuidics enables massively-parallel analysis of single cells, biomolecules, and chemicals, making it valuable for high-throughput screens. However, many hydrophobic analytes are soluble in carrier oils, preventing their quantitative analysis with the method. Synthetic biologists engineer organisms to produce value compounds, including drugs, biofuels, and chemical building blocks. The University of California applys Printed Droplet Microfuidics to construct defined reactions with chemicals and cells incubated under air on an open array. The method interfaces with most bioanalytical tools and retainshy drophobic compounds in compartmentalized reactors, allowing their quantitation. This experiment uses a multi-line laser that contain 405nm, 473nm, 532nm and 640nm that manufacutured by CNI Laser. Their paper is published in Scientific Reports. Paper title: An Oil-Free Picodrop Bioassay Platform for Synthetic Biology. Periodical: SCIENTIFIC REPORTS | (2018) 8:7913| DOI:10.1038/s41598-018-25577-4, page 5 06 Optical Diffraction Tomography Korea Advanced Institute of Science and Technology presents a multimodal approach for measuring the three-dimensional (3D) refractive index (RI) and fluorescence distributions of live cells by combining optical diffraction tomography (ODT) and 3D structured illumination microscopy (SIM). A digital micromirror device is utilized to generate structured illumination patterns for both ODT and SIM, which enables fast and stable measurements. They use CNI 473nm and 532nm single frequency lasers to complete the experiment, and the paper of this research is published in Scientific Reports. Paper title: Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device. Periodical: SCIENTIFIC REPORTS | (2018) 8:9183 | DOI:10.1038/s41598-018-27399-w 07 Optoelectronic Synaptic In recent years, optoelectronic synaptic devices have become the application platform for next generation neuromorphic system and artificial neural network. The key synaptic functions such as excitatory postsynaptic current (EPSC) and paired-pulse-facilitation (PPF) were successfully emulated by Human Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University. More importantly, by exposing an ultraviolet (360nm) laser (CNI Laser), the transformation of short-term memory (STM) to long-term memory (LTM) can be mimicked in our neuromorphic devices. These results represent an important step toward the next-generation neural networks enabled by photo-electric hybrid nano-electronics, and point to the potential of more sophisticated neuromorphic computations. Their paper is published in Solid-State Electronics, 2020 - Elsevier. Paper title: Poly(vinyl alcohol)-gated junctionless Al-Zn-O phototransistor for photonic and electric hybrid neuromorphic computation. Periodical: Solid-State Electronics, 2020 - Elsevier We feel very happy and honored that CNI lasers are helping more and more customers to successfully complete their research. All CNI staff will be dedicated to continually evolving our knowledge and experience to deliver innovative products and expertise that advance our customers.

FC-785 High Power FiberCoupled Laser System The High Power Fiber Coupled Laser System integrates laser, fiber coupled optics, laser power supply and temperature control into housing. It is coupled with a line generator at the fiber end. It has features of high power, perfect line uniformity and continuously adjustable line width. Line generator can be customized on request. High Power Fiber Coupled Laser System with its stable performance, high reliability works professionally in line-scanning Raman spectroscopy system. FEATURES •Output power up to 50W •Wavelength tolerance is 785±0.5nm • Spectral linewidth less than0.2nm • Lens angle of line generator isoptional

High Power Femtosecond Laser Features NarrowPulseWidth(<300fs) HighRepetitionRate HighOutputPower GoodBeamquality

Tissue Cassettes Printer Features: 1. Cold laser marking technology does not need ink, ribbon and other consumables; 2. Automatic robotic arm grab tissue cassettes transmission mode; 3. It can put in nearly 100 tissue cassettes at one time; 4. Fast printing speed, simple operation, and maintenance-free; 5. Patient information will never be lost and not confused; 6. The hopper can be easily installed without adjusting the angle; 7. The outlet groove can accommodate 6 tissue cassettes, and the extension module is optional; 8. Patient information can be imported by the LIS electronic medical record system; 9. Built-in air purification system and dust collector; 10. With full/lack tissue cassettes alarm function.

Spatial Light Modulator As a product carrier for digital optical technology applications, spatial light modulators can change the amplitude, polarization state or phase of light distribution in space under the control of time-varying electrical drive signals and other signals, or convert incoherent light into coherent light. It can easily write specific information into light waves to achieve the purpose of light wave modulation. Through the image signal, the voltage of each pixel is dynamically controlled in real time, so as to realize the modulation of light waves. The performance of spatial light modulators largely determines the application value and development prospects of modern optical fields such as optical information processing, adaptive optics and optical computing. ■ Reflective Spatial Light Modulator ■ Transmissive Spatial Light Modulator ■ Other Models

TS300 Laser Power Mete Features: Wavelength range: 0.19 -25µm Damage threshold: 45KW/cm2 Power measurement range: 0.5W-300W TS300-TP100 Active area diameter: 25mm

High Energy Diode Pumped Pulse Laser Features A variable attenuator and nonlinear crystal are integrated into the laser head. Uniform flat-top beam intensity distribution. Rep.rate(adjustable):1-100Hz Single wavelength output or quad-wavelength coaxial output options (1064nm/532nm/355nm/266nm). Pulse burst mode can stably output pulse energy. Display screen, software or communication protocol control methods can be selected. The laser head and power supply are integrated together. It can be used in LCD/OLED laser repair, LIBS and other fields. Energy stability <0.265%@1064nm Pulse width: 10.448ns@1064nm Near field laser beam @50mJ@1064nm Far field laser beam @50mJ@1064nm Near field laser beam @25mJ@532nm Far field laser beam @25mJ@532nm

Mini355 Laser Marking System Features: - 355nm violet wavelength, cold light source, suitable for marking on sensitive materials; - Air cooling without maintenance, long lifetime; - Excellent beam profile to achieve fine marking line; - Laser directly acting on molecular chain with maximum extend to avoid heat effect, without dust or smoke during marking. - Standard contrast > 300:1 Material: - Plastic (PC, PVC, PE, HDPE, ABS, PPR, PET, HIPS, PS, PP, PPO.PA.POM.PMMA...) - Consumer electronics - Insulation layer of capacitor and transformer - Tissue cassettes and slides Specifications Wavelength 355nm Peak power 10KW Focus length ~160mm Marking scope 110mm x 110mm Marking depth ≤0.2mm Maximum marking line speed 7000mm/s Minimum marking line width ≤0.1mm Power consumption ≤0.2KW Power requirement 220VAC/ 50Hz Gross Weight 22 KG

High Power Multi-wavelength Laser Features: Built-in driver for easy operation 375-1550nm wide range of wavelengths available 2-20 wavelengths can be combined into one system Customized wavelength and output power combinations Single or Multi Channel optional Customized size available Software controllable Applications: Medical Industrial Biomedicine Raman spectroscopy Channel type Single Channel Multi-Channel Model FC-MS FC-ML Customized model FC-MS-CH Available wavelength (nm) 375-1064 375-1550 Number of combined wavelengths 2-3 4-6 7-20 2-6 Fiber type SM, MM SM, PM MM Fiber core diameter (μm) Customized on request 4-9 (SM/ PM) 200/ 400 (MM) Fiber connector SMA905/ FC FC SMA905/ FC Output Power Customized on request Power stability (rms, over 4 hours) <5%, <3% <3%, <2%, <1% Operating Mode CW, TTL or analog on request Operating Temperature (℃) 10-35 Power input 100-240VAC Cooled Method Air cooled Expected lifetime (hours) 10000 Warranty 1 year Standard model: ◆405nm/ 447nm/ 532nm/ 637nm ◆405nm/ 488nm/ 532nm/ 637nm Type Dual-wavelength Narrow Linewidth Laser System Model FC-NL-532/ 785 FC-NL-784/ 785 FC-NL-785/ 1064 FC-NL-830/ 1064 Wavelength tolerance (nm) ±0.5 Output power (mW) 100/ 500 500/500 500/800 600/800 Fiber type MM Fiber core diameter (μm) 100, 0.22NA Fiber connector SMA905/ FC Power stability (rms, over 4 hours) <5%, <3%, <1% Spectral line width (nm) <0.1 Central wavelength stability (rms, over 2 hours) <10pm Operating Mode CW, TTL or analog on request Operating Temperature (℃) 10-35 Power input 12VDC Cooled Method Air cooled Expected lifetime (hours) 10000 Warranty 1 year

6-Channel Tissue Cassettes Printer Features: Cold laser marking technology does not need ink, ribbon and other consumables; Automatic robotic arm grab tissue cassettes transmission mode; It can put in 80x6 channels tissue cassettes at one time; Fast printing speed, simple operation, and maintenance-free; Patient information will never be lost and not confused; The hopper can be easily installed without adjusting the angle. Specifications: Model BTM-1-6C Wavelength 355nm Peak power 15kW Focus length ~160 mm Pulse width <5ns Marking speed ~3sec/pc Marking depth ≤0.1mm Minimum marking line width ≤0.05mm Power consumption ≤0.3kW Power requirement 100-240VAC/ 45-65Hz Size 310x320x320mm Weight 17 KG

ALL FIBER SUPERCONTINUUM SOURCE LASER Supercontinuum laser can cover the spectral output range from 470nm to 2400nm. It has the advantages of high stability, good beam quality, narrow pulse width and compact structure, which can be widely used in fiber component characterization, fiber sensing, broadband spectroscopy, fluorescence spectroscopy, scientific research, etc.

High Resolution Spectrometer-Aurora4000 Introduction: The Aurora 4000 series spectrometer uses 3648 pixel CCD linear array detector, its optical resolution up to 0.02 nm (FWHM), measuring spectral range of 185-1200 nm, with the characteristics of high speed spectral response and high resolution, suitable for applications in many fields. The system consists of incident slit, collimator mirror, dispersion element (grating), focusing optical system and detector. The spectrum is collected by optical fiber and read by the software (Spectral Analysis). Features: 14 at the bit A / D resolution Programmable circuit design USB 2.0 (USB 1.1 compatible) interface mode A CCD linear array detector Multiple trigger modes are supported Supports analog output Support secondary development of software Automatic peak finding and reading resolution

Picosecond Laser Series Applications: · High precision marking and cutting of glass · Metal / Ceramic / Sapphire marking / drilling / cutting · Cutting of LCD / OLED display panel · LED wafer dicing / Wafer scribing · SiP package circuit etching and cutting · Ink removal ... PS-D model Specifications: Higher frequency and higher power can be customized!